Human Hair Color Genes

Most of these genes have.

Human hair color genes. This receptor controls the type of melanin produced by the melanocytes. The findings were published online this week in the journal Nature Genetics. People with large amounts of pheomelanin have red hair which can range from pale red strawberry blond to bright red to reddish brown.

Hair color is determined by the amount of eumelanin which is dark brown and pheomelanin which is reddish. These partly-overlapping genetics help explain why a persons hair skin and eyes are sometimes similar in terms of being lighter or darker. Researchers have discovered 124 genes that play a major role in determining human hair color variation.

These pigments are coded for by different forms of the MC1R gene. Functional testing of variant alleles has begun to connect phenotype correlations with biological differences. The color of human hair is a multifactorial trait that generally depends on the interaction between the eumelanin and pheomelanin pigments.

Melanocortin 1 Receptor MC1R is the gene responsible for hair color determination. Some of the genes associated with hair color also influence eye color skin pigmentation and freckles. The amount of eumelanin ranges continuously from very little producing light-blonde hair to large amounts producing black hair.

This gene provides instructions for making a protein called the melanocortin 1 receptor which is involved in the pathway that produces melanin. It turns out hundreds of genes influence hair color. We found that a model based on a subset of 13 single or compound genetic markers from 11 genes predicted red hair color with over 09 black hair color with almost 09 as well as blond and brown hair color with over 08 prevalence-adjusted accuracy expressed by the area under the receiver characteristic operating curves AUC.

Human skin colour is highly heritable and externally visible with relevance in medical forensic and anthropological genetics. The genetic makeup of these traits-including polymorphisms in the enzymes and signaling proteins involved in melanogenesis and the vital role of ion transport mechanisms operating during the maturation and distribution of the melanosome-has provided new insights into the regulation of. The OCA2 gene is responsible for producing hair skin and eye color.